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二噁英对非洲爪蛙细胞色素P450表达的影响

董 武 胡玉晖 杨景峰 高原 解彦炯 王思珍 马国文

董 武, 胡玉晖, 杨景峰, 高原, 解彦炯, 王思珍, 马国文. 二噁英对非洲爪蛙细胞色素P450表达的影响[J]. 环境科学研究, 2006, 19(1): 87-90.
引用本文: 董 武, 胡玉晖, 杨景峰, 高原, 解彦炯, 王思珍, 马国文. 二噁英对非洲爪蛙细胞色素P450表达的影响[J]. 环境科学研究, 2006, 19(1): 87-90.
DONG Wu, HU Yu-hui, YANG Jing-feng, GAO Yuan, XIE Yan-jiong, WANG Si-zhen, MA Guo-wen. The Effect of Dioxin in Expression of Cytochrome P450 in Xenopus Embryos[J]. Research of Environmental Sciences, 2006, 19(1): 87-90.
Citation: DONG Wu, HU Yu-hui, YANG Jing-feng, GAO Yuan, XIE Yan-jiong, WANG Si-zhen, MA Guo-wen. The Effect of Dioxin in Expression of Cytochrome P450 in Xenopus Embryos[J]. Research of Environmental Sciences, 2006, 19(1): 87-90.

二噁英对非洲爪蛙细胞色素P450表达的影响

基金项目: 国家自然科学基金资助项目(30360090);教育部回国留学启动基金资助项目;新世纪优秀人才支持计划

The Effect of Dioxin in Expression of Cytochrome P450 in Xenopus Embryos

  • 摘要: 二噁英(代DD)是一类毒性较强的环境污染物质.试验使用印记法定量检测了非洲爪蛙芳烃基受体(从R)及其核内的转录因子(Amt),细胞色素P450(CYP)中的CYP1A6 mRNA及CYP1A7 mRNA;用免疫反应检测了CYP1A蛋白质的表达.结果表明:TCDD的染毒没有引起AhR和Arnt表达量的增加,但引起CYP1A6 mRNA及CYP1A7 mRNA表达的极显著增加,以及CYP1A蛋白质的强烈表达;TCDD强烈诱发非洲爪蛙CYP1A,且存在质量浓度依存性,使用CYP1A作为环境危险性评价具有一定的可探讨性.

     

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出版历程
  • 收稿日期:  2005-02-10
  • 修回日期:  2006-01-30
  • 刊出日期:  2006-02-25

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