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五氯酚钠与二英对人外周血淋巴细胞的影响

方 征 刘征涛 李 响 王婉华 李 霁

方 征, 刘征涛, 李 响, 王婉华, 李 霁. 五氯酚钠与二英对人外周血淋巴细胞的影响[J]. 环境科学研究, 2006, 19(2): 20-22.
引用本文: 方 征, 刘征涛, 李 响, 王婉华, 李 霁. 五氯酚钠与二英对人外周血淋巴细胞的影响[J]. 环境科学研究, 2006, 19(2): 20-22.
FANG Zheng, LIU Zheng-tao, LI Xiang, WANG Wan-hua, LI Ji. Infection of Lymphocyte from Human Peripheral Blood by Sodium Pentachlorophenate and Dioxins[J]. Research of Environmental Sciences, 2006, 19(2): 20-22.
Citation: FANG Zheng, LIU Zheng-tao, LI Xiang, WANG Wan-hua, LI Ji. Infection of Lymphocyte from Human Peripheral Blood by Sodium Pentachlorophenate and Dioxins[J]. Research of Environmental Sciences, 2006, 19(2): 20-22.

五氯酚钠与二英对人外周血淋巴细胞的影响

基金项目: 国家自然科学基金资助项目(40332033)

Infection of Lymphocyte from Human Peripheral Blood by Sodium Pentachlorophenate and Dioxins

  • 摘要: 将五氯酚钠(Na-PCP)与二(噁)英(2,3,7,8-TCDD)作为受试物,观察了人外周血淋巴细胞的彗星率和微核率.结果显示:Na-PCP与二噁英各质量浓度组的彗星率与微核率均比阴性对照组有明显的增高(P<0.001),而且随着质量浓度的增加而增高,呈明显的剂量-效应关系;阴性对照组与助溶剂对照组没有明显差异(P>0.05);Na-PCP与二(噁)英(2,3,7,8-TCDD)会对人外周血淋巴细胞的DNA造成损伤,而且随着质量浓度的增加,其对DNA的损伤将更加严重;Na-PCP对人外周血淋巴细胞造成的损伤为联合毒性所致.

     

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出版历程
  • 收稿日期:  2005-05-19
  • 刊出日期:  2006-04-25

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