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Cu2+和Cd2+对斑马鱼胚胎早期发育的联合毒性

张亚辉 刘征涛 王一喆 闫振广 王 宏 杨霓云

张亚辉, 刘征涛, 王一喆, 闫振广, 王 宏, 杨霓云. Cu2+和Cd2+对斑马鱼胚胎早期发育的联合毒性[J]. 环境科学研究, 2010, 23(11): 1415-1420.
引用本文: 张亚辉, 刘征涛, 王一喆, 闫振广, 王 宏, 杨霓云. Cu2+和Cd2+对斑马鱼胚胎早期发育的联合毒性[J]. 环境科学研究, 2010, 23(11): 1415-1420.
ZHANG Ya-hui, LIU Zheng-tao, WANG Yi-zhe, YAN Zhen-guang, WANG Hong, YANG Ni-yun. Joint Toxicity of Cu2+ and Cd2+ to Early Development of Zebrafish Embryos[J]. Research of Environmental Sciences, 2010, 23(11): 1415-1420.
Citation: ZHANG Ya-hui, LIU Zheng-tao, WANG Yi-zhe, YAN Zhen-guang, WANG Hong, YANG Ni-yun. Joint Toxicity of Cu2+ and Cd2+ to Early Development of Zebrafish Embryos[J]. Research of Environmental Sciences, 2010, 23(11): 1415-1420.

Cu2+和Cd2+对斑马鱼胚胎早期发育的联合毒性

基金项目: 国家水体污染控制与治理科技重大专项(2008ZX0526-003)

Joint Toxicity of Cu2+ and Cd2+ to Early Development of Zebrafish Embryos

  • 摘要: 采用斑马鱼胚胎早期发育技术,测定Cu2+和Cd2+ 2种重金属对胚胎发育的毒性效应. 以24 h致死和72 h胚胎孵化抑制为毒性终点,2种重金属的剂量-效应曲线可用Weibull函数或Logit函数有效描述,由最佳拟合函数计算得出半数致死浓度(LC50)或半数效应浓度(EC50)为毒性效应的评价标准,2个毒性终点的重金属毒性大小顺序均为Cu2+>Cd2+. 应用浓度加和(CA)与独立作用(IA)2种模型,对72 h孵化抑制率的无观测效应浓度(NOEC)配比混合物的联合毒性作用进行了预测,通过混合物试验观测数据的95%置信区间与CA模型和IA模型预测的剂量-效应曲线进行比较分析表明,2种模型都可以有效预测斑马鱼胚胎孵化的联合毒性.

     

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出版历程
  • 收稿日期:  2010-05-25
  • 修回日期:  2010-08-20
  • 刊出日期:  2010-11-25

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