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燃煤PM2.5不同组分对血管内皮细胞的毒性

刘芳盈 丁明玉 王菲菲 李 杰

刘芳盈, 丁明玉, 王菲菲, 李 杰. 燃煤PM2.5不同组分对血管内皮细胞的毒性[J]. 环境科学研究, 2011, 24(6): 684-690.
引用本文: 刘芳盈, 丁明玉, 王菲菲, 李 杰. 燃煤PM2.5不同组分对血管内皮细胞的毒性[J]. 环境科学研究, 2011, 24(6): 684-690.
LIU Fang-ying, DING Ming-yu, WANG Fei-fei, LI Jie. Cytotoxicity of Different Compositions of Coal-Fired PM2.5 on Vascular Endothelial Cells[J]. Research of Environmental Sciences, 2011, 24(6): 684-690.
Citation: LIU Fang-ying, DING Ming-yu, WANG Fei-fei, LI Jie. Cytotoxicity of Different Compositions of Coal-Fired PM2.5 on Vascular Endothelial Cells[J]. Research of Environmental Sciences, 2011, 24(6): 684-690.

燃煤PM2.5不同组分对血管内皮细胞的毒性

基金项目: 中央级公益性科研院所基本科研业务专项(2009KYYW05)

Cytotoxicity of Different Compositions of Coal-Fired PM2.5 on Vascular Endothelial Cells

  • 摘要: 采用MTS法评价燃煤PM2.5不同组分对血管内皮细胞EA.hy926的细胞毒性.以大同散煤为样品煤,在实验室采用固定源稀释通道采集燃煤PM2.5,提取燃煤PM2.5全颗粒物、无机组分及有机组分,分别对人脐静脉内皮细胞EA.hy926进行染毒,采用MTS法检测PM2.5不同组分对EA.hy926细胞增殖的影响.结果表明:燃煤PM2.5全颗粒物、无机组分及有机组分均可抑制血管内皮细胞增殖,且具有剂量-反应关系;在相同染毒剂量组内,有机组分的活性抑制影响显著高于全颗粒物和无机组分,其差异具有统计学意义,但全颗粒物和无机组分之间并无统计学差异.PM2.5的来源和组分是影响其细胞毒性的重要因素,燃煤PM2.5不同组分均可抑制血管内皮细胞增殖,血管内皮损伤是PM2.5致心血管毒性的可能机制之一.

     

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出版历程
  • 收稿日期:  2011-03-25
  • 修回日期:  2011-04-11
  • 刊出日期:  2011-06-25

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