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PSE-UPLC-MS/MS法测定污泥中9种药物与个人护理品

陈伟伟 黄 俊 隋 倩 余 刚 祝万鹏

陈伟伟, 黄 俊, 隋 倩, 余 刚, 祝万鹏. PSE-UPLC-MS/MS法测定污泥中9种药物与个人护理品[J]. 环境科学研究, 2011, 24(8): 925-932.
引用本文: 陈伟伟, 黄 俊, 隋 倩, 余 刚, 祝万鹏. PSE-UPLC-MS/MS法测定污泥中9种药物与个人护理品[J]. 环境科学研究, 2011, 24(8): 925-932.
CHEN Wei-wei, HUANG Jun, SUI Qian, YU Gang, ZHU Wan-peng. Determination of Nine Pharmaceutical and Personal Care Products in Sludge by PSE Coupled to UPLC-MS/MS[J]. Research of Environmental Sciences, 2011, 24(8): 925-932.
Citation: CHEN Wei-wei, HUANG Jun, SUI Qian, YU Gang, ZHU Wan-peng. Determination of Nine Pharmaceutical and Personal Care Products in Sludge by PSE Coupled to UPLC-MS/MS[J]. Research of Environmental Sciences, 2011, 24(8): 925-932.

PSE-UPLC-MS/MS法测定污泥中9种药物与个人护理品

基金项目: 国际科技合作重点项目(2007DFC90170)

Determination of Nine Pharmaceutical and Personal Care Products in Sludge by PSE Coupled to UPLC-MS/MS

  • 摘要: 利用加压溶剂萃取法(PSE)提取、固相萃取法净化并结合超高效液相色谱-串联四极杆质谱仪(UPLC-MS/MS)检测,建立了污水处理厂污泥中7个药剂类别的9种药物与个人护理品(舒必利、咖啡因、美托洛尔、氯霉素、萘啶酸、卡马西平、驱蚊胺、氯贝酸、苯扎贝特)的分析检测方法.在萃取方法中,对加压溶剂萃取的污泥质量和溶剂进行了优化;在净化方法中,对固相萃取柱种类、固相萃取柱容量、洗脱溶剂和洗脱量进行了优选.结果表明,方法检出限(以干质量计,下同)在2.7~65.0 pg/g范围内,加标回收率在67.0%~130%之间,相对标准偏差均小于25%(即标准偏差小于25 μg/L).应用所建立的分析方法,对北京某污水处理厂的脱水污泥进行了测定,9种目标物质含量为nd(未检出)~50.5 ng/g,其中,舒必利、咖啡因、卡马西平、驱蚊胺和氯贝酸在2010年春、夏季2次采样均有检出.

     

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出版历程
  • 收稿日期:  2010-12-14
  • 修回日期:  2011-01-20
  • 刊出日期:  2011-08-25

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