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高残留农药福美双对斑马鱼胚胎脊索的特异性影响

于永利 杨景峰 巴雅斯胡 王思珍 赵宝全 董 武

于永利, 杨景峰, 巴雅斯胡, 王思珍, 赵宝全, 董 武. 高残留农药福美双对斑马鱼胚胎脊索的特异性影响[J]. 环境科学研究, 2011, 24(11): 1297-1304.
引用本文: 于永利, 杨景峰, 巴雅斯胡, 王思珍, 赵宝全, 董 武. 高残留农药福美双对斑马鱼胚胎脊索的特异性影响[J]. 环境科学研究, 2011, 24(11): 1297-1304.
YU Yong-li, YANG Jing-feng, BA Yasihu, WANG Si-zhen, ZHAO Bao-quan, DONG Wu. Specific Effects of the Highly-Persistent Pesticide Thiuram on Notochord Development in Zebrafish Embryos[J]. Research of Environmental Sciences, 2011, 24(11): 1297-1304.
Citation: YU Yong-li, YANG Jing-feng, BA Yasihu, WANG Si-zhen, ZHAO Bao-quan, DONG Wu. Specific Effects of the Highly-Persistent Pesticide Thiuram on Notochord Development in Zebrafish Embryos[J]. Research of Environmental Sciences, 2011, 24(11): 1297-1304.

高残留农药福美双对斑马鱼胚胎脊索的特异性影响

基金项目: 国家自然科学基金项目(30360090);教育部新世纪优秀人才支持计划项目(NCET-04-0260);教育部回国留学人员支持项目

Specific Effects of the Highly-Persistent Pesticide Thiuram on Notochord Development in Zebrafish Embryos

  • 摘要: 福美双在我国是一种广泛使用的二硫代甲氨基甲酸盐类农药,它的高残留性已经引起世界各国的重视. 以斑马鱼胚胎作为试验动物模型,从分子水平探讨了福美双对胚胎脊索弯曲的毒性作用机制.结果表明,福美双造成斑马鱼胚胎脊索弯曲与重叠等形态学变化,脊索弯曲程度与福美双的染毒浓度呈正相关. 通过Ⅱ型胶原蛋白抗体染色表明,福美双引起软骨发育的变化与Ⅱ型胶原蛋白表达的降低密切相关. 试验进一步表明,斑马鱼胚胎适合作为农药毒性评价的模型.

     

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出版历程
  • 收稿日期:  2010-12-07
  • 修回日期:  2011-05-12
  • 刊出日期:  2011-11-25

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