Abstract: 11 kinds of cement pavement base specimens with different mixing ratios of oil-based drill cuttings (OBDC) were prepared, and unconfined compression strength, splitting tensile strength, and compressive modulus of resilience of the specimens were detected, in order to determine the specimen with the largest mixing ratio of OBDC and could meet the relevant mechanical properties. After that, the leaching test was carried out to study the leaching behavior of heavy metals, and different leaching models were used to predict the long-term cumulative leaching amount. The results reveal that: (1) unconfined compressive strength, splitting tensile strength and compressive modulus of resilience of the cement pavement base specimens decrease with the increment of OBDC content, with the mixing ratio of OBDC reaches to 12.0%, the relevant mechanical properties of the specimen could meet the requirements and, in this case, 12.0% of OBDC is the maximum mixing ratio. (2) Ba, Mn, Pb, and Zn are the characteristic heavy metal pollutants in OBDC. The cumulative leaching amount of Ba, Mn, and Pb reached to leaching equilibrium at 64 days, whereas the cumulative leaching of Zn continued to increase. Overall, the leaching behavior of these four heavy metals was affected by diffusion control. (3) Elovich equation could better describe the leaching behavior of Ba and Pb, while the second-order kinetic equation is more suitable to describe the leaching characteristics of Mn. The prediction of long-term heavy metal cumulative leaching amount indicated that more attention should be paid to Mn based on the leaching risk, when OBDC was used in preparing cement pavement base.