To establish a systematic and applicable thermally enhanced soil vapor extraction remediation model of organic contaminated sites and improve the prediction accuracy of the numerical model, a pilot site of the reagent plant in Tianjin was taken as the research object, the heating process of the site and the removal process of the target pollutant chlorobenzene were simulated based on the TMVOC model. The simulation data of the temporal and spatial distribution of the temperature field, and the dynamic removal of chlorobenzene were fitted with the actual pilot data to verify the reliability of the TMVOC model. The results showed that the fitting effect of the model is great. After seven weeks of simulated heating, the average temperatures of TCH-A and TCH-B were 99.4 °C and 84.8 °C, respectively. Then maintaining the temperature for a week, the average temperature of the two zones changed to 95 °C and 88 °C, respectively. The fitting degree of the temperature between the simulation data and the actual pilot data are 0.995 and 0.989, respectively. The removal rate of chlorobenzene reached 97.3% after eight weeks of simulated thermally enhanced soil vapor extraction. The removal rate was the slowest in the first week and the last week, and the removal rate was the fastest in the fourth week. The fitting degree between the simulation data of chlorobenzene concentration and actual pilot data is 0.91. This model can provide support for the application of thermally enhanced soil vapor extraction remediation technology in organic contaminated sites.