Abstract: To study the factors controlling the local chemical generation of ozone in key regions (Beijing-Tianjin-Hebei and surrounding areas, Yangtze River Delta region, Pearl River Delta region, Chengdu-Chongqing region, and Fenwei Plain) in China in recent years, ozone and precursor concentration data from a total of eight representative sites in these regions in summer and autumn from 2014 to 2019 were used to compare and analyze the volatile Organic compounds (VOCs) composition characteristics and their relationship with ozone chemical generation at eight sites in the five priority regions. The results showed that the VOCs concentrations in these five key regions were mainly composed of alkanes, while the active components were dominated by alkenes, oxygenated VOCs and aromatic hydrocarbons. Sensitivity analysis found that increases in temperature, radiation, or biogenic emissions may affect local ozone production, but do not change the determination of ozone production control areas. By using VOCs source resolution techniques and relative incremental reactivity, anthropogenic source categories such as motor vehicle exhaust, industry and solvent use were found to be the key VOCs emission sources affecting local ozone chemistry generation, while biogenic VOCs contribute significantly to ozone generation in rural or suburban areas (e.g., Wangdue and Taian sites). Therefore, if we want to reduce peak ozone concentrations in individual cities, it is necessary to implement differentiated precursor reduction strategies in order to effectively control VOCs according to the emission characteristics of each city and their impact on local ozone generation. Focusing on controlling anthropogenic VOCs is a key measure to effectively control summer ozone pollution.