Abstract: Aiming at the maximization of substrate degradation efficiency and methane production, the characteristics of mesothermal anaerobic digestion of kitchen waste under different feed total solids (TS) content (12%、15%、18%、25%、28%、33%) and organic load rate (8.5、10.5、13.5 gVS·L^-1·d^-1) were investigated, and the biogas residue characteristics and resource utilization potential under the optimal feed parameters were investigated. analysis. The results show that the TS of the feed is an important factor affecting the anaerobic digestion efficiency of kitchen waste. Adjusting the TS to 25% can obtain the maximum cumulative methane production of 16.81 L and the highest cumulative methane production per unit volume load of 42.01 L·L^-1, the volatile solids (VS) degradation rate reaches 72.29%, and the system runs stably. Under the condition of 25% TS, the cumulative methane production of the system increases first and then decreases with the increase of organic load. When the organic load rate is 10.5 gVS·L^-1·d^-1, the cumulative methane production of the system is the highest of 24.04 L, the VS degradation rate is the highest of 79.64%, and no acid inhibition phenomenon occurs; when the organic load increases to 13.5 gVS·L^-1·d^-1, the system stability decreases, volatile fatty acids accumulate in large quantities, and pH is rapid decrease, the activity of methanogens is inhibited, which eventually leads to the termination of the anaerobic digestion reaction. Under the above optimal TS and organic load rate, the by-product biogas residue produced in the anaerobic digestion process has high organic matter and total nutrient content, low electrical conductivity and heavy metal content, and suitable pH value, which meets the standards of "Organic Fertilizers" and "Organic Substrates for Greening", higher nutrients and lower biotoxicity make it have good potential for resource utilization; at the same time, it is found that the biogas residue has a high moisture content and a low seed germination index, so it is not suitable to be directly applied to the soil. It needs to be dehydrated and the degree of decay is improved before application.