Abstract: In situ chemical oxidation (ISCO) using persulfates is widely used for remediation of soil and groundwater contaminated by organic pollutants. During ISCO, injected persulfates transport in aquifers and undertake complex physical and chemical processes, dependent of aquifer characteristics and injection systems. How the transport and distributions of persulfates in aquifers vary with aquifers and injection systems remains poorly understood. As a result, it is difficult to predict the radius of influence (ROI) of persulfates in aquifers, denotated as the border at which 1 g/L persulfates occur and is the lower limit to ensure the performance of persulfates. In this study, we developed continuous single-well injection system scenarios in distinctly different aquifers with different injection parameters, and carried out numerical simulations on the transport and distributions of persulfates in aquifers using the numerical model FEFLOW. Totally 11 parameters were taken in considerations, related to aquifer characteristics, persulfate consumption and/or injection systems. Particularly, these parameters were composed of permeability, effective porosity, thickness, longitudinal dispersivity, hydraulic gradient, organic matter content and the ratio of transverse to longitudinal dispersivity of aquifers, the second-order rate constants of persulfates and organic matter, and injection flow rate, injection time and injection concentration of persulfates. Different combination equations of individual and/or interaction items of the 11 parameters were proposed to represent the impacts of hydrodynamic dispersion, persulfates consumption and their interactions on persulfate ROI in aquifers, respectively. By using the combination equation and mathematical simulating result data, we developed a comprehensive model for the temporal and spatial distributions of persulfate ROI in aquifers, with the determining degree (R²) of 0.990 (n = 2083). The external verification of transport of persulfates in aquifers had a R² value of 0.992 (n =11), based on the Advection-Dispersion Equation of persulfates in aquifers used by the model FEFLOW. Sensitivity analyses indicated that effect porosity and thickness of aquifers and injection flow rate and injection time of persulfates have great positive or negative impacts on persulfate ROI. Their impacts decreased or increased in magnitude over time, and the decreasing or increasing rates drastically varied with aquifers. Effects of injection and hydrodynamic parameters on persulfate ROI in typical aquifers were discussed to identify the best design of alternative injection approaches. The finding may have practical interest in the evaluation and optimization of persulfate-based ISCO, based on the site-specific conditions including aquifer permeability and heterogeneity as well as natural oxidant demand.