Abstract: Horqin Left Back Banner is located in a typical semi-arid sand area with heavy soil degradation and strong wind erosion. From the perspective of wind erosion prevention and land protection, optimization of land use structure will help regional sustainable development in terms of social, economic and ecological aspects in the interlaced agricultural and pastoral areas. This study applied the Revised Wind Erosion Equation (RWEQ) model for simulating wind erosion in the case area of Horqin Left Back Banner. Three future scenarios, considering historical development, whole area administration and regional administration, were development based on the CA-Markov model, local wind erosion conditions and related regional planning. The Dyna-CLUE model was further used to simulate land use patterns of Horqin Left Back Banner in 2020 for each developed scenario. The model results suggested that:(1) The wind erosion of Horqin Left Back Banner was intense with a clear spatial heterogeneity in the year of 2010, with an average value up to 33.86 t/(hm²·a). (2) The Kappa index of the simulated results for the year of 2010 was about 0.921, indicating that the Dyna-CLUE model has a good simulation performance. (3) The results for the historical development scenario suggested a serious trend of desertification and grassland degradation in Horqin Left Back Banner, and in particular the area of desert land was found to increase by 33.76%. The whole area administration scenario indicated an effective achievement in wind erosion control. 70.30% of the unused land was reclaimed, where 32.32% and 32.52% were converted to woodland and grassland, respectively. The water and wetlands areas were also restored, with an increase in total area by 5.01%. Compared to the whole area administration scenario, the regional administration scenario suggested that the reclaimed area of unutilized land in high wind erosion areas was even larger, meanwhile the area of arable land in low wind erosion areas was found to increase by 4.68%. Overall, this work suggested that the Dyna-CLUE model is robust in simulating land-use patterns for agricultural and pastoral ecotones in China; active sand prevention and control measures can significantly increase local forest land and grassland areas, and targeted sub-regional governance policies can effectively protect cultivated land while harnessing wind erosion.