Abstract: N-DBPs (e.g. DCAN) have received more attention in recent years, which were reported to be more toxic than C-DBPs (e.g. CF). One of the most effective ways to control the formation of DBPs was to remove its precursors before disinfection. To investigate the effect of microbial degradation on the formation of DBPs during subsequent chlorination and chloramination from DBPs precursors, this study selected CF and DCAN as the representative C-DBPs and N-DBPs, and selected Asp (aspartic acid) and Tyr (tyrosine) as the typical precursors to explore the effect of microbial degradation on the formation of DBPs. The results showed that after the degradation of Tyr and Asp, the removal rate of DOC was 94.0% and 85.6%, respectively, and the removal rate of DON was 69.0% and 81.0%, respectively. The amount of CF and DCAN during chlor(am)ination decreased greatly after biodegradation. The highest removal rates of CF and DCAN were reached 56.1% and 89.5% respectively when Tyr water sample was chlorinated. And the amount of CF was reduced by 68.5% for Tyr water sample during chloramination. For Asp water sample, the removal rate of DCAN reached 99.9% during chlorination, and the amount of CF reduced by 50.7% during chloramination. The microbial communities in water samples were analyzed. At the phylum level, Proteobacteria、Actinobacteria and Bacteroidetes were the dominant phylum. At the genus level, Burkholderia-paraburkholderia、Haliangium、Mycobacterium、Sediminibacterium、norank_f_chitinophagaceae and Zoogloea were the dominant genus. The research showed that biodegradation has great potential in controlling the formation of C-DBPs and N-DBPs. It is necessary to carry out the research on the control of multi-DBPs precursors by microbial degradation to realize the integrated control of DBPs.