Abstract: Lanzhou City plays a significant strategic fulcrum role in the 'Belt and Road' Initiative. Therefore, based on the ozone monitoring instrument (OMI) data products, this paper studied the correlation between the ozone column concentration, precursor compounds and meteorological factors in Lanzhou City from 2006 to 2015. The results showed that the column concentration of O₃ in the troposphere and total column concentration of HCHO increased first and then decreased with time, while the column concentration of NO₂ in the troposphere decreased gradually with time. Spatial correlation analysis between the column concentration of O₃ and NO₂ in the troposphere and total column concentration of HCHO showed that the correlation values of the three substances increased first and then decreased. In the view of sensitive control area, the sensitive control zone of VOCs gradually disappeared, and the scope of the VOCs-NO_x coordinated control zone was gradually reduced, while the scope of NO_x sensitive control zones gradually expanded. In terms of the meteorological factors, the column concentration of O₃ in the troposphere had a significantly positive correlation with air temperature and sunlight intensity, while it had a seriously negative correlation with the atmospheric pressure and rainfall. There was a relatively high column concentration of O₃ in the troposphere in Lanzhou City when the wind speed reached 1.7-1.9 m/s and the wind direction was northward. This study shows that the reduction of NO_x emissions can reduce the column concentration of O₃ in the troposphere significantly in Lanzhou City.