Abstract: During the outbreak of novel coronavirus pneumonia (COVID-19), chlorinated disinfectants were widely used. The chlorinated disinfectants will react with the organic matter in surface water, and the reaction products are chlorinated disinfection by-products (CDBPs). Common CDBPs include halomethanes, haloacetic acids, inorganic haloxate, haloacetonitriles, cyanogen halides, halonitromethane, haloacetaldehyde and other CDBPs. In view of the continued discovery and study of CDBPs, the types and hazards of CDBPs reported in the literature were reviewed. The results indicate that most of the CDBPs have 'three effects' of carcinogenic, teratogenic and mutagenic toxicity, threatening aquatic biosecurity and human health. Although the current research mainly focuses on CDBPs in drinking water, a few studies have confirmed that CDBPs are also detected in surface water. Because large amount of chlorine disinfectants are used during the COVID-19 outbreak, it is recommended to screen the main CDBPs in the surface water containing residual chlorine, conduct targeted monitoring, promot the rational use of disinfectants and strengthen supervision. CDBPs should be added to surface water quality standards and industry wastewater discharge standards. Finally, the secondary environmental impacts on the surface water ecosystems can be avoided.