Abstract: The concentration and spatial distribution characteristics of 61 pharmaceuticals and personal care products (PPCPs) in the surface water of Luoma Lake were investigated by the ultra performance liquid chromatography interfaced to tandem mass spectrometry (UPLC-MS/MS). Moreover, the risk quotient value (RQ) method was applied to assess the ecological risks of detected PPCPs. The results showed that: (1) Fifteen PPCPs were detected in the surface water of Luoma Lake with a concentration range of 2.67-6514.91 ng/L, including 7 types for humans use, 4 for humans and veterinary use, and 4 for veterinary use. The detection rate of carbamazepine (CBZ), N, N-diethyl-m-toluamide (DEET), sulpiride (SP), caffeine (CF) and lincomycin (LCM) was 100%. The highest average concentrations of DEET, thiamphenicol (TAP) and florfenicol (FF), were 162.87, 61.33 and 56.72 ng/L, respectively. (2) The concentration of PPCPs was higher in the north and west areas than in the south and east areas of Luoma Lake. There were slightly differences in the spatial distribution of various PPCPs: the concentration of human/veterinary PPCPs gradually decreased from north to south; the human PPCPs were slightly higher in the north; and the veterinary PPCPs were evenly distributed throughout the lake. (3) CBZ and CF in Luoma Lake were at high ecological risk. Enrofloxacin (ENR), norfloxacin (NOR), sulfadiazine (SD), roxithromycin (RXM) and LCM were at a medium to high level. Humans use PPCPs were the main source of ecological risk in Luoma Lake. The level of PPCPs in the surface water of Luoma Lake was moderate, and the pollution of DEET was serious. Therefore, the management of seine net and pond aquaculture in the northern lake area should be strengthened.