Abstract: In order to understand the adsorption characteristics of antibiotics on soil, the equilibrium oscillation method was used to study the sorption kinetics and thermodynamics of ciprofloxacin on subalpine meadow soil and marsh soil. Here, soil samples were collected in the northwest of Sichuan Plateau. The relationships between ciprofloxacin adsorption and soil physicochemical properties and environmental factors (temperature, solution pH and initial concentration) were quantified. The results showed that the adsorption kinetics of ciprofloxacin was best described by the pseudo-second-order model, and the correlation constant R² was 0.9202-0.9886. The adsorption thermodynamic process was in accordance with the Freundlich model, and the isotherm adsorption belonged to the L-type. At 15-35 ℃, the thermodynamic parameter analysis showed that Gibbs free energy (ΔG^θ) and Entropy (ΔH^θ) were less than zero, and Enthalpy (ΔS^θ) was greater than zero, indicating that the adsorption was a spontaneous exothermic reaction with an increase of chaotic degree accompanied mainly by physical adsorption to the surface. The adsorption capacity followed the order: marsh soil > subalpine meadow soil, and the adsorption capacity of the two soils was positively correlated with the initial concentration of ciprofloxacin. Moreover, in the pH range of 3-9, the adsorption of ciprofloxacin increased and then decreased with the increase of pH, the maximum adsorption on the two soils was obtained at pH 5. Thus, strong acid and alkali conditions were unfavorable to ciprofloxacin adsorption. The results had important implications that the adsorption capacity of different soils for ciprofloxacin was different, and ciprofloxacin adsorption on the two soils was strongly related to temperature, initial concentration of ciprofloxacin and pH.