Abstract: In order to understand the pollution characteristics of pharmaceuticals and personal care products (PPCPs) in the surface sediments of Luoma Lake, analyze their pollution sources and conduct ecological risk assessments, the ultra performance liquid chromatography interfaced to tandem mass spectrometry(UPLC-MS/MS) was used for detection. The results showed: (1) 14 kinds of PPCPs were detected in 14 samples and the PPCPs concentrations ranged from 0.02 to 330.02 ng/g. The detection rates were 7.14%-100.00%. Among them, the dominant pollution types were N, N-diethyl-m-toluamide(DEET), ketoprofen (KP) and caffeine (CF), which accounted for 41.96%, 16.85% and 15.65% of the total concent-ration, respectively. (2) The high concentration and common detection of DEET could be the multiple effects of pesticides, household care products and human activities. And the high concentration of CF was related to the random disposal of drinks and medicines. (3) According to the cluster analysis, the PPCPs pollution at sampling sites 1, 2, 9, 10 located in the bay area were more seriously. (4) According to the risk quotients, the ecological risk assessment showed that CF, ofloxacin (OFL) and sulfamethoxazole (SMX) were at high risk, which cannot be ignored. The concentration of PPCPs in the surface sediments of Luoma Lake was at a moderately low level compared with other lakes. However, the concentration of DEET was too high and CF had a certain ecological risk, which requires more attention.