Abstract: Water treatment separation membrane has nano-scale screening channels, which is suitable for decentralized treatment of oil-water emulsion in rural domestic sewage, but the membrane fouling is serious and energy consumption is high. Therefore, the design of anti-fouling and high flux water treatment separation membrane can achieve efficient treatment of oil-bearing domestic sewage in rural areas. In this study, PDA-NP films were prepared by vacuum-assisted self-assembly technology, and polydopamine (PDA)/polyethylene imine (PEI) nanoparticles were loaded on the surface and inside of polymer films. Because the nanoparticles contain rich hydrophilic groups, the recovery rate of pure water flux and rural oil-bearing domestic sewage flux is as high as (741.23±17) L/(m²·h) and 99.4%, respectively after modification, achieving the goals of high flux and anti-fouling. In addition, TOC removal rate of oil-bearing rural domestic sewage reached 45.12%, which has strong practical significance.