Abstract: Tetracycline wastewater treatment was tested by using immobilized anaerobic micro-bial beads,made by PVA-boric acid method.‘as the methane phase in a two-phase anaerobic process. And the comparison between PVA-beads methane reactor and UASB methane reactor was made. The results show PVA-beads reactor is more stable to shock load and of higher bio-logical activity,with COD removal efficiency of 65%-70%,higher than UASB methane reactor.