Abstract: GIS technology and USLE,SCS-CN,nutrient losses empirical equations and AnnAGNPS model were coupled to carry on control divisions of NPS in a mediumsized watershed,located in southeast of China,with relative strong intensive agricultural activities.The results show that the integration of GIS with empirical models can help analyze major sources and contributors of NPS,and identify the critical source areas of NPS.This can not only develop the advantages of empirical equations,e.g.requiring less model parameters,having large scale under study and being more efficient,but also realize simulation of watershed non-point source pollution and identify critical source areas of NPS through spatial analysis functions,increasing visual display effect of the results.After calibrating and validating the AnnAGNPS model,several scenarios were designed and simulated for suggestions of best management practices(BMPs).Finally,based on the quantitative results derived from GIS and the models,five control division units were generated for non-point source pollution control in Jiulongjiang River watershed,namely,soil losses controlling unit,livestock breeding & soil losses controlling unit,fertilizer use & livestock breeding controlling unit,soil losses & fertilizer use controlling unit and fertilizer use & soil losses controlling unit.