Abstract: Based on energy consumption in the industrial sector in the Pearl River Delta (PRD) in 2003, and emission factors from literature and experiments, a 4-km resolution industry emission inventory (EI) was developed for the PRD region. Compared with the EI in 2000, the total emission of SO₂ and NO_x increasedby 60% and 50%, respectively. The main sources emitting SO₂ and NO_x were located in Dongguan, Foshan, Guangzhou and Zhuhai. The Weather Research and Forecast (WRF) chemistry model (WRF-Chem) was used to investigate the contribution of modifiedindustrial emission sources to local air pollution with the two inventory data sets. The results showed that the changes of mass concentrations of SO₂ and NO_x were well correlated with the emission sources. Dongguan (180 μg/m³), Guangzhou (150 μg/m³) and Foshan (150 μg/m³) increased significantly in SO2 emissions, while Dongguan (60 μg/m³), Guangzhou (30 μg/m³) and Foshan (30 μg/m³) also had greater NO_x emissions. The change characteristics and trends of SO₄^2－ and NO₃^－ were different from SO₂ and NO_x. These results suggested that the concentration distributions of secondary pollutants were influenced not only by the emission sources, but also by the transport and transformation of the first pollutants.