Abstract: Based on environmental statistics, the freshwater wastage per unit output value and pollution generation intensity of major pollutants such as COD_Cr and NH₃-N of key industries in the Liao River Basin were analyzed and compared with those of the Songhua River Basin, Hai River Basin, Huai River Basin and China’s average level. The pollution generation characteristics were then analyzed. A scenario analysis model was designed to predict the total pollutant generation levels under given economic annual growth rates and different scenarios for pollution generation intensities of key industries in the river basin in 2015. The results showed that the industrial freshwater wastage per unit output value and pollution generation intensities of COD_Cr and NH₃-N in the Liao River Basin in 2008 were lower than China’s average values, and also lower than those of the Songhua River Basin, Hai River Basin and Huai River Basin. The COD_Cr pollution generation intensity of papermaking and paper products industry was 5.04 times that of the national average level. The COD_Cr pollution generation intensities of the non-ferrous metal smelting and pressing industries and raw chemical materials and chemical product industries were high, as were the COD_Cr and NH₃-N pollution generation intensities of the medical and pharmaceutical product industry. This showed that there is great potential for developing clean production in these industries. According to the results of the scenario analysis of reduction potential of pollutant generation quantity in the Liao River Basin, under the relatively reasonable High Scenario, COD_Cr and NH₃-N generation quantities are expected to decrease by 14% and 9% respectively in 2015 compared with that of 2008, which is favorable to total reduction of pollution discharge.