Abstract: Volatile organic compounds(VOCs)are crucial in air pollution such as haze and photochemical smog. VOCs emission inventory is essential in regional air pollution research and pollution control policy making. Anthropogenic VOCs emission sources were classified into more than 30categories. An anthropogenic VOCs emission inventory in Jiangsu Province for 2010has been developed based on statistical activity data and literature surveyed emission factors. New emission factor from local emission characterization has been included. The result shows that the total anthropogenic VOCs emission in Jiangsu was about 1.792×10⁶ t in 2010. The VOCs emissions are mainly contributed by fossil fuel combustion, biomass burning, industrial processes, solvent utilization, vehicles and storage and transport, which generated 4.32×10⁵,0.59×10⁵,4.00×10⁵,4.53×10⁵,3.30×10^5and 1.18×10^5t of VOCs, respectively. The industrial processes emissions contributed 22.3%, in which organic chemical industry, pharmaceutical manufacturing and oil refining industry were the key sources. The solvent utilization emissions shared 25.3% of the total amount, in which machinery coating and electronic equipment manufacturing were the key sources. Emissions of 13cities in Jiangsu Province was estimated respectively. The result illustrates that high emissions mainly concentrate in developed regions. Five cities in the south Jiangsu(Nanjing, Suzhou, Wuxi, Nantong and Changzhou)contributed 60.0% of the total emissions, much higher than that of the cities in north Jiangsu. Suzhou, Nanjing and Wuxi were the three cities with the highest emission amount. Fossil fuel combustion and vehicle emissions contributed more than 10.0% of the total amount in 13cities. The considerable variation of the VOCs inventory between the cities indicates different predominant contributors. The oil refining industry was the key source in Nanjing. Organic chemical industry and machinery equipment industry were the key sources in Suzhou. Organic chemical industry and electronic equipment manufacturing were the key sources in Wuxi. Emission of VOCs in the study still have high uncertainties, which suggests that more fundamental studies on local emission sources are needed to improve the emission inventory in the future.