Abstract: Acetamiprid used in plant and soil has widely drawn more and more attentions due to its actions type and environmental toxicity in recent years. In order to probe the environmental transformation characteristic, the chemical oxidation degradation kinetics of acetamiprid were carried out in Fe²⁺/S₂O₈^2-/EDTA aqueous solution. Various parameters such as the concentration of Fe²⁺, S₂O₈^2- and EDTA, affecting on degradation efficiencies were investigated by single-variable-at-a-time (SVAT) and central composite design (CCD) based on response surface methodology (RSM). The results showed that the degradation efficiency of acetamiprid was achieved as 58.25% after 360minutes reaction. The oxidizing ability of Fe²⁺/S₂O₈^2-/EDTA was significantly affected by the concentration of Fe²⁺, S₂O₈^2- and EDTA, respectively. The degradation optimum conditions of acetamiprid were obtained by CCD as follows:EDTA as 1.61mmol/L, Fe²⁺ as 3.46mmol/L and S₂O₈^2-as 7.99mmol/L in Fe²⁺/S₂O₈^2-/EDTA aqueous solution. Additionally, the degradation efficiencies of acetamiprid were attributed to reactive oxidation species (ROSs), and the neutral solution was favor for generating ROSs in Fe²⁺/S₂O₈^2-/ EDTA aqueous solution. However, due to certain amounts of ROSs in Fe²⁺/S₂O₈^2-/ EDTA aqueous solution, the higher concentration of acetamiprid (>200μmol/L) retard its degradation obviously, and then lead to lower degradation efficiencies. These results provide fundamental information necessary for the environmental transformation characteristic by ROSs in environmental water.