Abstract: To investigate chemical characteristic pollutants bound to the particulate matter, Lanzhou City was selected as the target city to monitor and analyze the concentration of 22major chemical pollutants such as Benzopyrene, Pb, Cr and Ni. In order to screen chemical characteristic pollutants, a combination of comprehensive evaluation and Hasse diagram method was applied to screen characteristic pollutants from atmospheric particulate matter in Lanzhou City according to the atmospheric pollution characteristics (history) and situation. At first, comprehensive evaluation has been used to screen characteristic pollutants of 22chemical pollutants in the particulate matter. The index system was composed of 9indices including environmental detection rate, potential damage index and environmental health influence degree, and the total score was 280. The results showed that Benzopyrene (the total score was 272, below), Pb (262), Cr (262), Ni (262), Cd (262), Cu (246), Benzoanthracene (230), Dibenzo a,h anthracene (215), Zn (214), Benzenefluoranthene (212) had a greater score and need to be pay much attention to. Similarly, the 22pollutants were screened by Hasse diagrams, the results showed that Benzopyrene, Pb, Cr, Dibenzo a,h anthracene, Ni, Cd, Cu, Zn,Benzoanthracene were in the front of Hasse diagram. On the base of comprehensive evaluation method, the Hasse diagram method was adopted to screen chemical characteristic pollutants. The results revealed that selected chemical pollutants could be divided into 5levels by their hazards (ranked in descending order):(1) Benzopyrene, Pb and Cr, (2) Ni, Dibenzoa,h anthracene, (3) Cu, Cd, (4) Benzoanthracene, Zn, (5) Benzofluoranthene. In conclusion, the combination of two methods has not only simplified the Hasse diagram method, but also achieved a more accurate hazard ranking for the characteristic pollutants, which has rationalized pollutants screening result.