Abstract: For pollution control of amantadine pharmaceutical wastewater and for resource recovery, complexation extraction process was employed to treat the amantadine wastewater. The influences of initial pH value, type of diluents, extractant composition, oil-to-water ratio and temperature on amantadine extraction efficiency were investigated, and the amantadine in extractant was recovered by back-extraction. The results showed that the extraction efficiency of amantadine was above 99.7% under the conditions of initial pH value 8.0, oil-to-water ratio 1∶1 and temperature 25 ℃ by using P₂₀₄-octanol ratio 3∶2 complex extractant. In the process of back-extraction, P₂₀₄-octanol ratio 1∶4 octanol complex extractant could achieve higher back-extraction efficiency. HCl solution of 1.0 mol/L was used as stripping agent, and with the oil-to-water ratio of 1∶1, about 51.7% amantadine was stripped from the loaded solvent. The recycled amantadine hydrochloride solution could be reused in the amantadine production process. P₂₀₄-octanol complexation extractant could be used repeatedly in the extraction and back-extraction processes. The results showed that complexation extraction is a feasible process for amantadine wastewater treatment, which can realize both pollution control and resource recovery.