Abstract: Methods for assessing groundwater environmental risks are urgently needed to prevent pollution and facilitate development of scientific and rational groundwater protection measures. Methods for assessing regional groundwater environmental risk were developed, and a classification and grading evaluation process was conducted following step-by-step regional risk screening plan. During the process, different regional scales were high lighted and divided into three main levels:large-scale (basins, plains), middle-scale (city, unit) and small-scale (water sources, pollution site). For the large-scale areas, based on the way of “risk source-receptor-endanger-ecological endpoint,” the analysis of regional groundwater environment at a large scale was established. Land use types were employed to indicate the regional pollution sources, quantity and quality of groundwater were the ecological endpoints, and the relative risk model (RRM) analysis was applied for evaluation of regional environmental risks. For the high risk regions in the large scaled areas, the “source-path-receptor” model was applied for groundwater pollution risk assessment for the urban scale, combining with the characteristics of local pollution source, hydrogeological condition and regional groundwater quality, to describe the risk of contamination area. The process simulation method, a small-scale groundwater environmental health risk assessment based on the theory of health risk assessment, with the purpose of security water supply, was taken for the detailed risk area, to determine the migration of contaminants in the unsaturated zone-groundwater and the effects of quantitative analysis on human health. The developed methods were subsequently applied to identify the key risk areas in the Lower Liaohe River Plain. The results showed that the Hun River Alluvial and Flood Fan is at higher environmental risk of contamination, while the Xi River has a higher groundwater health risk; accordingly, appropriate protective measures should be taken for regional groundwater prevention.